Cardio and Zone 2: the evidence behind the trend
Zone 2 is useful, easy to recover from and a good base. It is not the only intensity that matters, and a 2025 review argues it is not the best one for most people.
Zone 2 became popular through podcasts and elite endurance coaching. The idea is that long, easy sessions below the lactate threshold build the mitochondria and fat-burning capacity of muscle, and that this is the foundation of metabolic health. Part of that is true. Part of it is an extrapolation from elite athletes that the evidence in ordinary adults does not support.
What Zone 2 is
Zone 2 is low-intensity exercise below the first lactate threshold. In practice it is a pace where you can hold a conversation in full sentences but would rather not sing: a brisk walk uphill, an easy cycle, a slow jog for fitter people. Heart rate zones from a watch approximate it, but the formulas vary and individual thresholds differ, so the talk test is as good a guide as most.
Why fitness is worth chasing
Cardiorespiratory fitness, usually measured as VO2 max or METs on a treadmill test, is one of the strongest predictors of how long people live.
| Study | Year, journal | Who and how many | Design and length | Main result |
|---|---|---|---|---|
| Kodama et al. | 2009, JAMA | 33 studies, 102,980 participants | Meta-analysis of cohort studies | Each 1-MET higher fitness: 13% lower all-cause mortality (RR 0.87). Low vs high fitness: RR 1.70 for death |
| Mandsager et al. | 2018, JAMA Network Open | 122,007 patients referred for treadmill testing | Retrospective cohort, median 8.4 years | Lowest vs elite fitness: adjusted HR 5.04 for death. No upper limit of benefit observed |
| Milanovic et al. | 2015, Sports Medicine | 28 controlled trials, 723 healthy adults aged 18 to 45 | Meta-analysis of training trials | VO2 max rose 4.9 ml/kg/min with continuous endurance training and 5.5 with interval training vs no exercise; intervals had a possibly small extra effect (1.2 ml/kg/min) |
| Storoschuk et al. | 2025, Sports Medicine | Narrative review | Review of Zone 2 training studies | Evidence does not support Zone 2 as the optimal intensity for mitochondrial or fat-oxidation capacity; higher intensities matter more at low training volumes |
The first two are observational: fitter people live longer, but fitness tracks with many other things. The training trials show that fitness can be raised by both continuous and interval training, and the cohort data suggest raising it is worth doing.
What the 2025 review argued
Storoschuk and colleagues, writing in Sports Medicine in 2025, looked specifically at whether Zone 2 is the best intensity for improving mitochondrial capacity and fitness in the general population. Their conclusion: the case for Zone 2 rests largely on observations of elite endurance athletes who train for many hours a week, mostly at low intensity. In people with a few hours a week, the evidence points to higher intensities doing more for mitochondrial capacity and cardiometabolic health. Zone 2 still works; it is just not uniquely effective, and it needs a lot of time.
How much cardio the guidelines ask for
The US Physical Activity Guidelines and the WHO both set 150 to 300 minutes a week of moderate-intensity aerobic activity, or 75 to 150 minutes of vigorous activity, or a mix. Seventy-five vigorous minutes count the same as 150 moderate ones. The guidelines also say that more brings additional benefit, and that the least active gain the most from any increase.
Telling the intensities apart
| Intensity | Energy cost | Examples | Talk test |
|---|---|---|---|
| Light | Under 3 METs | Slow walking, household chores | Easy to talk and sing |
| Moderate | 3 to 5.9 METs | Brisk walking, easy cycling, doubles tennis | Can talk in sentences, cannot sing. Zone 2 sits here |
| Vigorous | 6 METs or more | Running, fast cycling, swimming laps, hill intervals | Only a few words at a time |
A MET is the energy cost of sitting quietly; 3 METs is three times that. Fitness changes where a given activity falls: a brisk walk is moderate for most people, vigorous for someone very unfit and light for a trained runner. The talk test adjusts for that automatically.
A sensible mix
- Mostly easy. Two to four sessions of 30 to 60 minutes at a conversational pace. This is where Zone 2 fits: it is easy to recover from, low in injury risk and builds the habit.
- Some hard. One session a week of intervals once you have a base: for example, four to six efforts of three to four minutes at a hard but controlled pace, with equal easy recovery. This is the part that raises VO2 max fastest.
- Walking counts. Brisk walking is moderate intensity for most people. See daily steps.
- Keep the strength work. Cardio does not replace the two days of muscle-strengthening the guidelines ask for. See strength training for beginners.
If you have heart disease, chest pain on exertion, or have been inactive for a long time with risk factors, check with a clinician before starting hard intervals.
Measuring progress at home
Without a lab test, three signals are useful. Resting heart rate, taken the same way each morning, tends to fall as aerobic fitness improves. The pace or power you can hold at the same easy effort tends to rise. And many watches estimate VO2 max from heart rate and pace; the absolute number is an estimate with real error, but the trend over months on the same device is informative. Compare yourself with yourself, not with the chart on the watch.
Cardio and weight loss
Aerobic exercise burns energy and improves fitness and blood sugar, but on its own it does less to protect muscle during weight loss than resistance training. The 2025 GLP-1 nutrition advisory recommends both: at least 150 minutes of moderate aerobic activity a week plus strength training at least three times a week. See exercise to keep muscle during weight loss.
Logging it
Zone 2 is defined by intensity, so heart rate and time matter more than distance. Peptide AI pulls workouts, heart rate and resting heart rate from Apple Health, Oura, WHOOP and Garmin through wearable integrations and puts them next to the training log. Resting heart rate falling over months is one of the simplest signs that the cardio is working.
Questions people ask
What is Zone 2 training?
Low-intensity aerobic exercise below the first lactate threshold, roughly a pace where you can talk in full sentences. It is easy to recover from and builds an aerobic base.
Is Zone 2 better than high-intensity intervals?
Not for most people with limited time. A 2025 Sports Medicine review concluded the evidence does not support Zone 2 as the optimal intensity for mitochondrial capacity, and a 2015 meta-analysis found intervals raised VO2 max slightly more than continuous training.
How much cardio should I do a week?
The US Physical Activity Guidelines and WHO recommend 150 to 300 minutes of moderate activity or 75 to 150 minutes of vigorous activity a week, plus strength training on two or more days.
Why does cardiorespiratory fitness matter?
It is strongly linked to longevity. In a 2009 JAMA meta-analysis, each 1-MET higher fitness level was associated with 13 percent lower all-cause mortality.
Sources
- Much ado about Zone 2: a narrative review of Zone 2 training for mitochondrial capacity and fitness (Storoschuk et al.), Sports Medicine, 2025
- Effectiveness of high-intensity interval training and continuous endurance training for VO2max improvements: meta-analysis (Milanovic et al.), Sports Medicine, 2015
- Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events: a meta-analysis (Kodama et al.), JAMA, 2009
- Association of cardiorespiratory fitness with long-term mortality among adults undergoing exercise treadmill testing (Mandsager et al.), JAMA Network Open, 2018
- The Physical Activity Guidelines for Americans, 2nd edition (Piercy et al.), JAMA, 2018
- World Health Organization 2020 guidelines on physical activity and sedentary behaviour (Bull et al.), British Journal of Sports Medicine, 2020
- Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from ACLM, ASN, OMA and TOS, American Journal of Clinical Nutrition, 2025
