GLP-2

GLP-2, the other glucagon-like peptide

GLP-2 shares a gene with GLP-1 and almost nothing else. It works on the gut lining, not appetite. Here is what it does and the drugs built on it.

15 October 2026 2 min read Editorial policy

GLP-1 and GLP-2 are cut from the same precursor in the same gut cells, but they act on different receptors and do different jobs. GLP-1 drugs are about blood sugar and appetite. GLP-2 drugs are about the intestine itself, and the approved one treats short bowel syndrome. These pages keep the two apart.

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The PeptideAI protocol screen with a weekly GLP-1 dose on it.